![]() These registries were 100% complete, that is, we did not lose track of even a single individual. Diagnoses of MI ( International Classification of Diseases, Eighth Revision codes 410 and Tenth Revision codes I121–I122) were obtained from the national Danish Patient Registry and the national Danish Causes of Death Registry, while information about any death was obtained from the Danish Civil Registration System. An MI diagnosis was based on characteristic symptoms, electrocardiographic changes, and/or elevated cardiac enzymes. ![]() We observed all individuals from 1976 until May 2009. We included 39 531 subjects investigated in 2003–2007 from the CGPS (45% participation rate), on all of whom MPV measurements were performed. Participants gave written informed consent. The study was approved by Herlev Hospital and a Danish ethical committee (H-KF-01-144/01), and was conducted according to the Declaration of Helsinki. ![]() We used individuals from the Danish general population (the Copenhagen General Population Study, CGPS). For these purposes we studied 39 531 individuals selected at random from the Danish general population. ![]() We tested the hypothesis that MPV is associated with risk of MI independently of known cardiovascular risk factors. Hence, MPV has a potential as a marker of platelet activation and may represent a risk factor for MI, dependent or independent of other cardiovascular risk factors. Nevertheless, it has been observed that known cardiovascular risk factors such as smoking, diabetes mellitus, obesity and hypertension are associated with MPV. Autoanalysers have routinely measured MPV together with platelet counts for decades, but clinical use of the measurement has been disregarded due to lack of convincing evidence that this measurement adds valuable information in the clinical situation. Platelet size measured as mean platelet volume (MPV) possibly is a simple and accurate way to estimate platelet activity. The central mechanism is the formation of a platelet-fibrin plug at the site of a ruptured atherosclerotic plaque, potentially leading to myocardial infarction (MI).Ī subpopulation of active platelets consists of large platelets. Conclusions: Increased MPV is associated with increased risk of MI independent of known cardiovascular risk factors.Īctivated platelets play an important role in the pathogenesis of coronary artery disease. Finally, in prospective, multifactorially adjusted analyses, risk of MI increased by 38% (8–75%) in individuals with MPV ≥ 7.4 vs. Use of antiplatelet therapy did not modify these risk estimates. Compared with the 1st quintile of MPV, there was corresponding increased risk of MI of 13% (−7% to 39%), 35% (11–64%), 31% (8–59%) and 29% (6–57%) in the 2nd, 3rd, 4th and 5th quintile, respectively. Results: After multifactorial adjustment for known cardiovascular risk factors, risk of MI was increased by 37% (95% CI, 18–59%) in the middle and 30% (12–52%) in the upper vs. Methods: We examined 39 531 men and woman from the Danish general population (the Copenhagen General Population Study), of whom 1300 developed MI. Objectives: We tested the hypothesis that increased MPV is associated with risk of MI in the general population independent of known cardiovascular risk factors. Platelet size is measured automatically as mean platelet volume (MPV) together with platelet count. Background: Active platelets are large and contribute to development of myocardial infarction (MI).
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